Dreaming of Antigone is the story of sixteen year old Andria Williams, whose twin sister, Iris, died of a heroin overdose six months ago. Her father suicided when the girls were very young, and she lives with her mother and step-father Craig. Still deep in grief, Andria has withdrawn from her friends Natalie and Trista at school, but finds solace in stargazing in the middle of the night and reading poetry with dark, philosophical themes, including the work of American poets Robert Frost, and Emily Dickinson, and Sylvia Plath. She dresses like an emo, though occasionally wears items from Iris’ more colourful wardrobe underneath her own black clothes.
Since she was a baby Andria has suffered from epilepsy, which has prevented her from participating in regular activities. She has a seizure dog, Sophie, whom she adores. Her mother is overprotective and nags her daughter about her diet, sleep, and whether or not she is taking her anti-seizure medication. From previous experience, Andria has learnt that her medication does not mix well with other drugs, and while her friends drink and smoke pot, she is a diet coke drinking teetotaller, particularly since her sister’s tragic death.Because of her epilepsy, Andria hasn’t been able to get her driver’s license. The seizure she had just before Iris died prevented her from taking her driving test then, and the narrative of Dreaming of Antigone begins with her counting down the final fourteen days until she can again attempt to get her license after going six months without having a fit.
In a boring algebra class, she begins writing fragments from her favourite poems on the surface of her desk, and is thrilled when her graffiti is answered by another mysterious lover of poetry. After several exchanges, she realises that her correspondent is Alex Hammond, her sister’s former boyfriend, who has just returned from a rehab centre to overcome his addiction to drugs and alcohol. Though she hates him for corrupting Iris, Andria is also attracted to handsome, brooding Alex, who plays drums in a rock band and works at the local café run by his lesbian moms. Andria and Alex end up earning extra credit together cataloguing poetry books in the school library, and their relationship grows stronger through unexpected encounters when Andria is stargazing and at parties, where they are the only two sober guests. But despite their chemistry, they are uncertain of each other’s feelings, and both worry that getting together in the aftermath of Iris’ death may be a bad idea.
To everyone’s shock, Andria’s stepfather Craig is charged with sexually abusing one of the girls on the soccer team that he coaches. Andria and her mother finally find Iris’ diary, which reveals that Craig has been molesting her for several years. Neither of them had any idea, and must face the guilt and horror that Iris’ addiction to drugs was fueled by her abuse. The stress causes Andria to have a seizure at school two days before her driving test, and when she goes to record the event in her seizure diary, she discovers a note from Iris, written the night she died, and revealing that she deliberately overdosed using Andria’s epilepsy medication. In a flashback sequence, the novel revisits the night of Iris’ death, and Andria confronts her own experience, including faking a seizure in an attempt to protect her sister, who died while the rest of the family was at the hospital. These terrible revelations are shared with the police, and Craig is charged. Andria’s mother longs to start a new life somewhere else, but Andria feels supported by her girlfriends and by Alex, who begins to understand that Iris was terribly damaged and that her death was not his fault. He accompanies her on a long awaited trip to see a meteor shower in the local cemetery, where they also visit Iris’ grave.
